Grinding Teeth at Night Can Be Related to Stress

If you know somebody who is given to grinding teeth during sleep, it can be a telltale sign that the person is suffering from some kind of stress. Well that’s what results of a recent study conducted on persons who grind their teeth at night by Heinrich-Heine-University, Dusseldorf, Germany show. This habit of teeth grinding, called as ‘sleep bruxism’ is quite a common phenomenon but so far no reason could be established as to what caused it.

In this study 69 adults were examined of whom 48 were already known to have bruxism. For this purpose thin plates were attached to the teeth of the subjects overnight to assess the extent of grinding. The same individuals were also made to answer questionnaires to take stock of what’s going on in their life and how much stress they are under in their personal or professional front.

Dr.Maria Giraki who headed the team which conducted the tests says in her report that while factors like age, sex or education didn’t seem to affect bruxing, there was a striking connection with those who claimed to be under stress in day to day life or work. The ones who suffered the most were those who didn’t know how to deal with the stress effectively, she said.

The journal, Head & Face Medicine will carry the details of the study.

Bruxism in the long run can lead to excessive wear and tear to teeth, looseness and sensitivity. It can also cause growth and pain in the muscles responsible for chewing. Now with this study establishing stress as a reason for this habit, maybe a solution is also on the way.

For nore info, visit : http://en.wikipedia.org/wiki/Bruxism.

Written by Priya Shankar

First Trial Over for Indian Made H1N1 Vaccine

Ahmedabad: Zydus Cadila announced completion of the first phase of the H1N1 vaccine trial on Thursday. The Ahmedabad-based drug maker will now commence the phase II and phase III clinical trials in Ahmedabad, Bangalore, Jaipur and Pune.

An Indian made H1N1 vaccine is on the way. The Ahmedabad based drug company Zydus Cedilla who is making the vaccine in India and has announced the completion of the first phase trial on Thursday. The vaccine has to go through the second and third trial in Ahmedabad, Bangalore, Jaipur and Pune now which will take six more months.

The company’s press release said “Multi-centric trials extending for a period of six weeks are currently underway. On successful completion of the trials, the group will submit the results to the Drug Controller General of India (DGCI) for marketing approval.” The vaccine has been developed by a team of experts using conventional technology at the company’s Vaccine Technology Centre here, the statement said.

The Indian made vaccine will be available in market by April 2010. The company is proposing to produce six million doses initially. The H1N1 vaccine is in huge demand in India to the extent of 50 to 60 million dosages initially.

At the same time the vaccinations against H1N1 in India will begin from next week itself, using the 1.5 million doses of vaccine imported from the French drug manufacturer, Sanofi Pasteur that has passed the safety test. The clinical bridge study results conducted on 100 adult subjects in Delhi and Pune were submitted to the Drug Controller General of India on Wednesday by the company. The trials were completed on February 21. The results were then checked thoroughly in Lyon before being submitted to DCGI.

DCGI Dr Surinder Singh told TOI, "The trials of the vaccine have proven its safety profile. By Friday, we will vet the results and give its clearance for use on humans in India. By next week, the vaccination should begin."